Regeneron Pharmaceuticals Principal PPK/PD Kineticist in Tarrytown, New York
We are looking for a PPK/PD Principal Scientist role will involve supporting PK and PK/PD (PPK/PD) requirements for Discovery and IND-stage project teams.
A day in the life of the Principal Scientist may look like:
Serve on Discovery-stage project teams as a subject matter authority for Preclinical Pharmacokinetics / Pharmacodynamics, providing input to the design of preclinical PK/pharmacology studies.
Collaborate optimally with various groups within Regeneron, including Therapeutic Proteins, Therapeutic Function Areas, Assay Development, Precision Medicine, Preclinical Operations and PPK/PD management developing a PK strategy for each project and then delivering the required output.
Effectively communicate project team queries, requests and expectations (i.e. timing and results) from the Project Teams to management.
Conduct and report PPK/PD analyses using data derived from preclinical studies.
Work in close association with the Toxicology, Pathology, Clinical Pharmacology (CP) and Quantitative Pharmacology (modeling & simulation) functions, within the Drug Safety and Pharmacometrics (DSP) Department, to deliver the required data and study reports / regulatory documents to support project progression.
We feel this might be the role for you if:
You want to work in a fast-paced, highly collaborative culture
You have a passion for Science, and want to help bring new drugs to people in need
You want exposure to multiple Therapeutic areas and new modalities
To be considered qualified we require:
A PhD in Pharmacology, Pharmacokinetics, Biology/Molecular Biology, Biochemistry, with >8 years of relevant, proven experience (Biotech or Pharma).
An in-depth theoretical and applied understanding of PK and PD, in order to describe and understand the pharmacology/biology of therapeutic proteins
A proven track record to plan, coordinate and lead all aspects of PK and/or PK/PD studies, and analyze PK/PD data.
Excellent communication (written/verbal), presentation and leadership skills
Knowledge of and experience with relevant PK/PD software applications (e.g., WinNonLin) is desirable, as is experience in drafting PK reports and relevant IND sections.
Previous experience with protein/monoclonal antibody therapeutics in one or more of the following therapeutic areas: oncology, inflammation / immunology, metabolism, infectious disease or ophthalmology.
Additional experience with other modalities, including siRNA, gene therapy, CAR-T and other modalities is helpful, but not required, and can be trained.
Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
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