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Life Science Research Professional 1

School of Medicine, Stanford, California, United States

Research

Post Date Sep 21, 2023

Requisition # 100759

Dr. Taia Wang’s laboratory in the Institute for Immunity, Transplantation, and Infection (ITI) at Stanford University is seeking a highly motivated Life Science Research Professional 1 (LSRP 1) to assist in our studies of antibodies, vaccine responses, and pathogenesis of viral infections. We use in-vivo and in-vitro systems and a variety of technologies to answer interesting questions related to immunity and disease.

Studies in our lab are driven by the hypothesis that IgG repertoire diversity is a central driver of heterogeneity in human immune functioning and susceptibility to diseases. We are specifically interested in the diversity that exists in the Fc domain repertoire among people, which we define by serum IgG subclass and Fc glycoform distributions. We have found that the Fc domain repertoire of an individual impacts key immune processes such as vaccine responses and susceptibility to antibody-dependent enhancement of dengue disease. This is because IgG subclasses and Fc glycoforms dictate the structure of Fc domains within immune complexes that form during vaccination or infection. This in turn determines the affinity of immune complexes for various Fc receptors on effector cells. Thus, our research seeks to define how the Fc domain repertoire of an individual determines the quality of effector cell responses that can be recruited during immune activation.

The LSRP1 will be expected to perform tasks that support the entire laboratory including maintenance of a large mouse colony, producing recombinant proteins, maintaining stocks, and updating inventories. The LSRP1 will have opportunities to contribute to research projects and perform independent experiments that further the project goals. The position offers room for growth and further opportunities.

Duties include:

• Manage the laboratory’s mouse colony by utilizing mouse handling skills, maintaining detailed records, interpreting genotype results, and communicating with veterinary staff.

• Perform general lab maintenance tasks including, but not limited to, producing commonly used proteins and plasmids, maintaining stocks, updating inventories, and providing general lab support as needed.

• Plan approach to experiments in support of research projects in the lab based on knowledge of scientific theory.

• Independently conduct experiments; maintain detailed records of experiments and outcomes.

• Apply the theories and methods of a life science discipline to interpret and perform analyses of experiment results; offer suggestions regarding modifications to procedures and protocols in collaboration with senior researcher.

• Review literature to remain current with new procedures and apply learnings to related research.

• Maintain extremely detailed records of laboratory work and outcomes.

*- Other duties may also be assigned

The expected pay range for this position is $53,000 to $76,000 per annum/hour.

Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.

At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards) provides detailed information on Stanford’s extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.

DESIRED QUALIFICATIONS:

• Experience and proficiency with basic methods of molecular biology (ELISA, PCR, cloning, Western blots), cell culture, and in-vivo systems.

• Experience with basic mouse handling.

• Familiarity with mouse breeding and mouse models of virus infection.

• Proficiency in cloning and recombinant protein production.

• Experience with tissue culture based virus growth, titer assays, and neutralization assays.

• Excellent lab notebook practices and attention to detail.

• Ability to multitask efficiently and accurately.

• 2+ years of experience in a research laboratory.

• Bachelor’s degree in Biology, Immunology, Microbiology, or similar.

EDUCATION & EXPERIENCE (REQUIRED):

Bachelor's degree in related scientific field.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):

• General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.

• Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.

• Ability to maintain detailed records of experiments and outcomes.

• General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.

• Ability to work under deadlines with general guidance.

• Excellent organizational skills and demonstrated ability to accurately complete detailed work.

CERTIFICATIONS & LICENSES:

None

PHYSICAL REQUIREMENTS*:

• Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.

• Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.

• Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.

• Must have correctible vision to perform duties of the job.

• Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.

• Ability to lift heavy objects weighing up to 50 pounds.

• Ability to work in a dusty, dirty, and odorous environment.

• Position may require repetitive motion.

*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

WORKING CONDITIONS:

• Requires working in close proximity to blood-borne pathogens.

• Requires work in an environment where animals are used for teaching and research.

• Position requires the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.

• Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.

• May require extended or unusual work hours based on research requirements and business needs.

Additional Information

• Schedule: Full-time

• Job Code: 4945

• Employee Status: Regular

• Grade: E

• Requisition ID: 100759

• Work Arrangement : On Site