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Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

The Cell Line Development Group in South San Francisco, CA is seeking a Scientist I to join a talented and collaborative team developing CHO cell lines for GMP applications.

In this laboratory position the candidate will perform hands-on CHO cell line development and characterization studies in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies. The work will encompass molecular, cellular, and bioprocess development studies relating to the generation and characterization of optimized CHO cell lines for production of our cancer pipeline candidates.

Key Responsibilities:

• Perform CHO cell line development, including transfection, selection, Beacon subcloning, flow cytometry analysis, fed-batch growth and productivity screening, cell banking and stability assessment of cell banks.

• Aseptically culture mammalian cells in suspension cultures across multiple scales and formats, from 96-well plates up to shake flasks and microbioreactors.

• Operate instruments like ViCell automated cell counter, Octet, Clone Select Imager, microscope, HPLC, ambr15, Beacon and flow cytometer. Share responsibility for equipment maintenance and supplies.

• Present updates at cross-functional meetings and collaborate closely with cell culture, purification, analytical and formulation development colleagues to meet project timelines.

• Actively seek opportunities to optimize or enhance the cell line development workflow.

• Display effective organization, verbal and written communication skills, and adherence to good documentation practices, including real time entry of lab work into electronic lab notebook.

• Author detailed technical reports that support regulatory filings at all stages from IND to BLA.

• May publish or present scientific findings in peer-reviewed journals, internal or external conferences or consortia.

Qualifications

• Bachelors Degree with a minimum of 5 years or Masters Degree with a minimum of 2 years of relevant experience

• Proficiency in developing stably transfected CHO cell lines for production of protein biologics including mAbs and antibody like molecules.

• Proficiency with sterile mammalian suspension cell culture from 96w to shake flask scales; cell transfection; flow cytometry.

• Strong understanding of mammalian cell biology and bioprocess engineering concepts.

• Independently generate precise, reliable and reproducible data in a timely manner. Demonstrate experimental precision and strong data interpretation skills and should possess understanding of core discipline.

• Excellent attention to detail and ability to keep detailed written records in lab notebook on a daily basis.

• Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions.

• Demonstrated ability to learn, understand and master new experimental techniques.

• Demonstrated ability to work collaboratively within and outside of the group.

• Demonstrated ability to author technical reports and presentations.

• Proficient with Microsoft Office software and able to learn new software applications.

• Able to multi-task and work within timelines.

• Strong communication skills – verbal, written, scientific data presentation.

Preferred:

• Experience with Beacon

• Experience with FACS cell sorting

• Experience with ambr15 operation

• Experience with automated liquid handling systems

• Familiarity with Chemistry, Manufacturing and Controls (CMC) and specifically CHO cell line development for GMP applications within biotech/pharma industry. Familiarity with relevant ICH guidelines.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

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AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html