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RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

The laboratory-based role offers an opportunity to help bridge laboratory research with clinical applications to advance novel Radiopharmaceutical Oncology therapies. As a translational scientist you will develop and execute in vitro, ex vivo, and in vivo models that recapitulate human cancer biology to identify tumor indications, test rational therapeutic combinations, and understand mechanisms of radio-resistance. The ideal candidate will be a critical thinker and a technical problem solver who enjoys working in interdisciplinary team settings. The role requires an ability and willingness to work with radioactive isotopes.

Key Responsibilities:

• Develop, optimize and utilize preclinical in vitro and in vivo models that mimic human cancer biology to evaluate drug efficacy, mechanism of action, and resistance mechanisms.

• Help develop and run cell- and tumor-based assays to support rational combination strategies, identification of mechanisms of resistance to RPT agents, selection of lead tumor indications, and identification of potential biomarkers that predict patient response to therapies.

• Work with radioactivity in various assays in strict adherence to the radiation safety protocols.

• Work under the guidance of project team leaders to support the overall translational plan; work closely with biology, chemistry, DMPK, imaging and in vivo teams to ensure appropriate prioritization of experiments.

• Generate, organize, and maintain meticulous records on all conducted experiments. Independently analyze and interpret data and present experimental plans and results at project team meetings, group meetings, and company meetings.

• Actively contribute to the experimental design and planning efforts to help achieve project goals under tight timelines.

• Collaborate with colleagues in other functional areas including biology and chemistry.

• Assist in laboratory operation management duties.

Education & Experience:

• BS with 4+ years of experience or MS 2+ years of experience within Cancer Biology, Molecular/Cell biology, Pharmacology, or a related discipline with hands-on laboratory experience.

• Hands-on expertise with human tumor-based assays and cell-based instruments (e.g. IncuCyte and Flow Cytometers) are required.

• Prior experience of working on drug discovery projects in an industrial setting is highly desirable.

Skills:

• Ability to work with radioisotopes with strict adherence to radiation safety protocols.

• Ability to execute experiments, including preclinical model development (e.g., cell lines, animal models, patient-derived models), to investigate disease mechanisms and evaluate therapeutic interventions.

• Familiarity and hands on experience with invitro, cell-based assay development and optimization and proficiency with cell culture, molecular biology techniques, ELISA, flow-cytometry, western blot, qPCR, immunohistochemistry and related protocols.

• Creativity and adaptability to explore new research methodologies, technologies, and approaches that enhance translational research outcomes.

• Familiarity with drug development process and interfacing and working with interdisciplinary teams.

• Excellent written and oral communication and presentation skills and ability to work in a fast-paced, dynamic, and collaborative environment.

• Strong interpersonal, organizational and communication skills.

• Proficiency in data analysis techniques, including statistical methods.

T he starting compensation for this job is a range from $92,601-$125,285, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.

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If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

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Company: Bristol-Myers Squibb

Req Number: R1585200

Updated: 2024-09-17 04:22:41.727 UTC

Location: San Diego-CA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.