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Job Title: Scientist I, Radiochemistry

Location: San Diego

Background

RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC) and breast cancer. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

Summary

The Scientist will be responsible for conducting research, experiments, and analysis in the field of radiochemistry. This role involves radiolabeling of diagnostic and therapeutic radioisotopes of peptides, small molecules, and/or antibodies as well as quality testing for in vitro and in vivo work. The Scientist will work in laboratory settings, collaborating with interdisciplinary teams to advance scientific knowledge and contribute to the advancement of all RayzeBio’s internal programs.

Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

• Develop and optimize experimental procedures ad methods, as well as conduct experiments to radiolabel peptides, small molecules and/or antibodies using various isotopes including but not limited to: Lu-177, Ac-225, Cu-64, Ga68 and Zr89

• Develop and execute methods for the characterization of radiolabeled compounds, using techniques such as radio-HPLC and radio-TLC chromatography to analyze purity and stability

• Develop novel methods and conduct in vitro assays (e.g. plasma stability and metabolite analysis) with radiolabeled compounds

• Prepare compounds for cell-binding assays and in vivo biodistribution and dosimetry studies

• Evaluate and present all radiolabeling methods and analytical results in functional meetings to provide input to progress internal programs

• Develop, interpret, and maintain appropriate documentation using GxP guidelines, including radiolabeling protocols, reports and data analyses

• Maintain a clean and safe working environment

Education and Experience

• A Ph.D or Master’s degree in radiochemistry, chemistry, nuclear chemistry, or related field

• A minimum of 5 years of experience in radiochemistry, radiopharmaceutical, and/or CMC development field

• Demonstrated experience in radiochemistry techniques and quality control instruments including but not limited to radioHPLC, TLC, gamma counter, gamma spectroscopy

• Proper radiation safety practices during radiosynthesis, radioanalytical chemistry operations, and when physically within the lab areas at all times

• Ability to work both collaboratively and independently in a fast-paced and cross-functional environment

Skills and Qualifications

• Hands on experience working with radioactive materials and radiation instrumentation in a radiochemistry laboratory setting.

• Highly motivated and organized professional with the ability to work both with a team and independently

• Multi-disciplined scientist with ability to troubleshoot

• Excellent professional ethics, integrity, and ability to maintain confidential information

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company: Bristol-Myers Squibb

Req Number: R1580766

Updated: 2024-05-17 01:01:52.379 UTC

Location: San Diego-CA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.