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University of Utah Post Doc Res Assoc w/Ret in Salt Lake City, Utah

Open Date 07/12/2021

Requisition Number PRN26889B

Job Title Post Doc Res Assoc w/Ret

Working Title Post Doc Res Assoc w/Ret

Job Grade A00

FLSA Code Administrative

Patient Sensitive Job Code? No

Standard Hours per Week 40

Full Time or Part Time? Full Time

Shift Day

Work Schedule Summary

TBD

VP Area U of U Health - Academics

Department 02072 - Pulst/Scoles Research

Location Campus

City Salt Lake City, UT

Type of Recruitment External Posting

Pay Rate Range 20000 to 500000

Close Date

Open Until Filled Yes

Job Summary

The Stefan Pulst / Daniel Scoles Neurology Laboratory group at the University of Utah, Department of Neurology, invites applications for a postdoctoral fellowship for the study of neurodegenerative diseases using calcium imaging and electrophysiological recordings. The Neurology Laboratory is well-funded by NIH , and other funding sources. We seek a highly motivated PhD in a related medical science who is interested in carrying out research on how RNA granules control localized calcium abundance and neuronal function in cultured cells and acute brain slices. The research objectives include understanding mechanisms of neurodegenerative disease as well as testing novel therapeutics in disease models.

The postdoc will join a well-established research program focused on developing therapeutics for cerebellar ataxia, amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer’s disease, Parkinson disease using mouse models and iPSC neuronal models combined with antisense oligonucleotide ( ASO ) or AAV microRNA -based therapeutics. The cellular mechanisms underlying these neurodegenerative diseases will be evaluated using a combination of two-photon imaging to monitor calcium abundance changes, live imaging for monitoring the movement of RNA granules, and electrophysiological recordings.

Located on the upper campus of the University of Utah, the position offers exceptional opportunities for interdisciplinary collaboration with a diverse group of investigators in both the Department of Neurology and the College of Pharmacy with a wide range of interests relative to the area of investigation, and a rigorous focus on developing therapeutics for neurodegenerative diseases.

Responsibilities

The postdoc will plan, design, and conduct experiments that are related to the project. Experiments may involve classical cell and molecular biology techniques, cloning, transfection, cell culture assays, AAV gene delivery in mice, electrophysiological recordings, and two-photon imaging.

·Perform physiological recordings in acute slices.

·Perform pharmacological studies driving discovery process.

·Incorporate immunohistochemical staining to broaden electrophysiology findings.

·Data interpretation, manuscript preparation, publication, presentation of results.

Minimum Qualifications

Preferences

Applicants should be highly motivated, have a Ph.D., at least 1 year of experience with extracellular or patch-clamp electrophysiology in acute brain slices. Experience with two-photon imaging would be a plus. Other requirements include laboratory, analytical, and organizational skills, verbal and written communication skills, and the ability to work in a team.

·Experience with electrophysiological recordings in acute slices

·Experience with 2-photon imaging

Type Benefited Staff

Special Instructions Summary

Additional Information

The University of Utah values candidates who have experience working in settings with students from diverse backgrounds and possess a strong commitment to improving access to higher education for historically underrepresented students.

Individuals from historically underrepresented groups, such as minorities, women, qualified persons with disabilities and protected veterans are encouraged to apply. Veterans’ preference is extended to qualified applicants, upon request and consistent with University policy and Utah state law. Upon request, reasonable accommodations in the application process will be provided to individuals with disabilities.

The University of Utah is an Affirmative Action/Equal Opportunity employer and does not discriminate based upon race, ethnicity, color, religion, national origin, age, disability, sex, sexual orientation, gender, gender identity, gender expression, pregnancy, pregnancy-related conditions, genetic information, or protected veteran’s status. The University does not discriminate on the basis of sex in the education program or activity that it operates, as required by Title IX and 34 CFR part 106. The requirement not to discriminate in education programs or activities extends to admission and employment. Inquiries about the application of Title IX and its regulations may be referred to the Title IX Coordinator, to the Department of Education, Office for Civil Rights, or both.

To request a reasonable accommodation for a disability or if you or someone you know has experienced discrimination or sexual misconduct including sexual harassment, you may contact the Director/Title IX Coordinator in the Office of Equal Opportunity and Affirmative Action:

Director/ Title IX Coordinator

Office of Equal Opportunity and Affirmative Action ( OEO /AA)

135 Park Building

Salt Lake City, UT 84112

801-581-8365

oeo@utah.edu

Online reports may be submitted at oeo.utah.edu

For more information: https://www.utah.edu/nondiscrimination/

To inquire about this posting, email: employment@utah.edu (%20employment@utah.edu) or call 801-581-2300.

The University is a participating employer with Utah Retirement Systems (“URS”). Eligible new hires with prior URS service, may elect to enroll in URS if they make the election before they become eligible for retirement (usually the first day of work). Contact Human Resources at (801) 581-7447 for information. Individuals who previously retired and are receiving monthly retirement benefits from URS are subject to URS’ post-retirement rules and restrictions. Please contact Utah Retirement Systems at (801) 366-7770 or (800) 695-4877 or University Human Resource Management at (801) 581-7447 if you have questions regarding the post-retirement rules.

This position may require the successful completion of a criminal background check and/or drug screen.

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