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University of Rochester Postdoctoral Fellow - 228208 in Rochester, New York

Postdoctoral Fellow Job ID 228208

Location School of Medicine & Dentistry Full/Part Time Full-Time Favorite Job Regular/Temporary Temporary Opening

Full Time 40 hours Grade 000 Psychiatry M&D Research

Responsibilities

Project Area

Human Neonatal T Cell Immunity

Newborns are susceptible to more frequent and severe infections with viruses and other intracellular pathogens, pointing to potential differences in how their T cells function. IN addition to protection from infection, T cells play a central role in maintaining immune homeostasis and orchestrating responses to microbial and inflammatory threats. To better understand T cell intrinsic differences that explain altered immune responses and adverse health outcomes, we apply single cell (genomics, proteomics) and advanced modeling techniques using human cells collected as part of a large longitudinal pregnancy/birth cohort.

We are seeking a highly motivated post-doctoral fellow who is eager to learn, apply and develop novel approaches to investigating the developing immune system in human infants, by working collaboratively within a team of translational researchers.

Project Description

Human Neonatal T Cell Immunity

The current projects uses mass cytometry and computational techniques to characterize changes in T cell functional and phenotypic heterogeneity over the first year of life, how pre-, peri- and postnatal clinical exposures influence T cell maturation, and how such developmentally-determined differences influence neurologic outcomes. Focused projects exploring more mechanistic hypotheses use single-cell genomics and epigenetics to reveal unique molecular underpinnings of fetal T cell functional programs.

Position Details

The Fellow will oversee the design, planning and performance of specialized research assignments related to phenotyping the immune response in humans. The fellow would work independently and collaboratively within affiliated research teams to develop and optimize innovative techniques and analytic/bioinformatic approaches for modeling human immune responses across gestational ages and longitudinally. The position is NIH grant-funded for a minimum of 2 years, and the Fellow will be invited to develop novel methods and hypothesis-generating discoveries that will support independent career advancement.

Qualifications

  • MD or PhD in Immunology or related field

  • Experience working with human tissue, flow sorting, flow cytometry, mass cytometry, multiplex assays

  • Fluency in DIVA, FCSExpress or other cytometry-specific analytic tools, R-package or Matlab, PRISM, Adobe Illustrator or Inkscape, R-package or Matlab, Loupe Browser, alternative bioinformatics tools

  • Experience with molecular biology and omics techniques

  • Experience working in a team-based research setting

    How To Apply

All applicants must apply online.

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