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Job Description

Title: Postdoc

Salary: $81,370

Department: Oncological Sciences

Physical work location: Hess building - 1470 Madison Ave, 10029 New York (NY)

Name PI or Supervisor: Emily Bernstein, PhD – emily.bernstein@mssm.edu - 212-824-9335

Web link to Lab: https://labs.icahn.mssm.edu/bernsteinlab/

Web link to Department: https://icahn.mssm.edu/about/departments-offices/oncological-sciences

Administrative Contact: Donnaann Chiodi – donnaann.chiodi@mssm.edu

Evelyn Markov – evelyn.markov@mssm.edu

Qualifications

Educational and other Requirements for the position:

A PhD in molecular biology, cancer biology or biochemistry is required, as well as 3-5 years of post-doctoral experience in the field of cancer epigenetics or similar. The successful candidate will have a strong publication record, including at least one first-author publication in a peer-reviewed journal.

Experience Required:

The ideal candidate will have the ability to think deeply about a problem and test it experimentally, demonstrate strong verbal and written communication skills, exhibit strong time management skills, and be a collaborative team player.

Goals/Outcomes of the Research Project:

The candidate is expected to produce novel and significant research that will expand our understanding of the molecular mechanisms linking chromatin remodelers and transcription factors and how this impacts cancer establishment and/or progression. Impactful preliminary results will be used to apply to different funding agencies and will be ultimately collected in a high-impact publication.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 824 - Oncological Sciences - ISM, Icahn School of Medicine

EOE Minorities/Women/Disabled/Veterans

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.?

Responsibilities

Details of Research Project:

The Bernstein lab is seeking to hire a highly skilled scientist to elucidate the role of chromatin remodelers in cancer. In particular, ATRX deletions drive a unique transcriptional program that promotes silencing of neuronal differentiation genes through altered genomic binding and novel protein partners. To tease apart what drives altered ATRX binding, what effect that has on transcription and cell fate, and what novel binding partners exist for ATRX IFFs, isogenic model systems have been created that the candidate will study. These models are crucial in determining changes to the epigenome and transcription that are directly related to the in-frame fusion of ATRX in found in neuroblastoma.

Technical Duties:

The ideal candidate will have expertise in the following (or similar) experimental strategies: protein biochemistry, cell culture and gene editing (e.g., CRISPR), cell-based phenotypic assays, chromatin assays & analyses (e.g. ChIP, CUT&RUN, ATAC-seq) in the context of cancer biology. The candidate’s anticipated duties will include a wide range of Next Generation Sequencing (NGS) approaches, the ability to produce and handle large data sets and navigate public cancer databases. As senior Postdoc in the lab, the candidate is also expected to train students and/or other incoming lab members, contribute to grant writing and assist the PI with further administrative duties ( e.g. seminar organization).Candidate will be expected to apply for postdoctoral fellowships and publish impactful papers.

About Us

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

• Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.

• Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.

• Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.

Explore more about this opportunity and how you can help us write a new chapter in our history!

“About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”

EOE Minorities/Women/Disabled/Veterans

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.