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JOB DESCRIPTION

THE INSTITUTION

The Icahn School of Medicine at Mount Sinai ( https://icahn.mssm.edu/ ) is a top ranking school among Basic and Clinical Science (2022 Blue Ridge NIH Rankings) comprising 44 research, educational, and clinical institutes, 36 academic departments, more than 300 research labs, more than 7,000 faculty (full-time, part-time, and voluntary), and 27 faculty members elected to the National Academy of Medicine and/or the National Academy of Sciences. At MSSM there are unparalleled opportunities to promote bold thinking and innovative approaches to discovery, towards a new era in precision medicine, to tackle diseases once thought incurable.

With a focus on innovation in education, research and patient care, MSSM trains scientist and physicians to become world scientific leaders that will make significant contributions to local and global health care.

The Liver Cancer Program at the Icahn School of Medicine at Mount Sinai is situated in New York City. It is structured as a multidisciplinary group comprising of hepatologists, surgeons, oncologists, pathologists, radiologists, genetics and genomics experts and basic scientists exploring novel models of disease, mechanisms of inflammation and signaling, fibrosis and gene therapy. The Mount Sinai Liver Cancer Program has achieved remarkable success, including more than 270 publications, with international leadership of 5 clinical trials and around 10 active clinical trials on HCC and cholangiocarcinoma.

RESPONSIBILITIES

The Liver Cancer Program at Icahn School of Medicine at Mount Sinai, New York, is seeking a motivated individual for the position of Junior Postdoctoral Research Fellow . The Principal Investigator, Prof. Josep M Llovet, is Professor of Medicine and Director of the Mount Sinai Liver Cancer Program. As a key member of our team, you will play a crucial role in liver cancer translational research by designing and executing studies with human samples and experimental models.

The main goal of our laboratory is to unravel the molecular determinants of liver cancer onset and progression, identify novel treatments for hepatocellular carcinoma (HCC) patients and discover predictors of response to molecular and immune therapies. We lead an International Consortium devoted to liver cancer research, and have produced important contributions in the field over the past years.

Research projects may involve, but are not limited to: 1) analysis of the tumor microenvironment of HCC by applying cutting edge technologies such as single cell sequencing; 2) generation of novel animal models of the disease; and 3) therapeutic targets discovery in sophisticated in vitro systems. Current areas of interest include the mapping of the immune cell microenvironment in human HCC related to non-alcoholic steatohepatitis (NASH), the identification of biomarkers of response to treatments (including immune checkpoint inhibitors and combinations), and the development of mouse models and innovative preclinical models that recapitulate specific NASH-HCC features to test the efficacy of novel therapies and assess their mechanisms of action. Our efforts are supported by several national and international grants, including an NCO-RO1 starting August 2023.

The candidate will work within a multidisciplinary team of basic biologists, physician scientists, computational biologists, and clinicians at the Icahn School of Medicine at Mt Sinai in the Division of Liver Diseases. The candidate’s duties will also include supervision and mentoring of PhD students and project coordination. The position and environment offers opportunities for career development, leadership experience, and scientific publications and presentations.

QUALIFICATIONS

REQUIREMENTS

• PhD in a research field related to cancer translational medicine

• Advanced level in written and spoken English

• Proven track record of first-author publications

• Hardworking and motivated

REQUIRED EXPERIENCE

• Experience in cancer research

• Stays abroad (>1 year), preferably in worldwide recognized scientific institutions.

Additional preferred skills :

• Experience in cancer molecular biology

• Experience in cancer genomics

• Experience in immunology

• Experience in animal modeling of cancer

• Experience in bioinformatics

To apply , please submit a cover letter, CV, proof of merits exposed and the degree obtained, and 2 reference letters to josep.llovet@mountsinai.org and yun.li@mssm.edu .

Please include "Post-Doctoral Research Fellow Application Your name " in the subject line.

Mount Sinai is an equal opportunity employer, and we encourage applications from individuals of all backgrounds. We value diversity and inclusion in our research community.

Application Deadline, salary and benefits: Applications will be evaluated until a suitable candidate will be identified. Salary will be based on experience and assigned according NIH policy. Mount Sinai provides a competitive package which includes subsidized housing and health insurance.

Please note that only shortlisted candidates will be contacted for an interview.

Non-Bargaining Unit, 033 - Liver MSH - ISM, Icahn School of Medicine

ABOUT US

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

• Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.

• Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.

• Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.

Explore more about this opportunity and how you can help us write a new chapter in our history!

“About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”

EOE Minorities/Women/Disabled/Veterans

Requisition ID : 3006748