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Job ID352081 LocationTwin Cities Job FamilyResearch-Researchers Full/Part TimeFull-Time Regular/TemporaryRegular Job Code9742R5 Employee ClassAcad Prof and Admin About the Job An NIH-funded postdoctoral research position is available in Dr. Skinner's laboratory at the University of Minnesota. The Skinner lab includes a diverse group of students, post-docs, and staff. Our lab is located in the Microbiology Research Facility that is part of the Biodiscovery District in Minneapolis. Our group is focused on the development of novel therapies to treat HIV and prion diseases. We are looking for individuals to join us in our efforts to cure HIV. We are seeking a highly motivated individual with a passion for research to join our research program. We found that HIV-specific cytotoxic lymphocytes, whose job it is to track down and kill virally infected cells, are largely excluded from lymphoid B cell follicles where HIV producing cells are most concentrated. This suggests that B cell follicles are somewhat of an immune privileged site that allows ongoing viral replication. We are now working to develop a cellular immunotherapy to target HIV-specific CTL to B cell follicles to allow an HIV infected individual's own immune system to control HIV replication in the absence of antiretroviral drugs. This position provides outstanding opportunities for continued scientific development, and for contributing to highly impactful pioneering translational research. Job duties: 80% Research: Planning and performance of complex daily and weekly experiments. This position requires the candidate to have the ability to correctly prepare and execute experiments with little direction from a senior researcher and/or defined protocols. The candidate must have the desire and ability to provide ongoing intellectual contributions to the research program such as exploring new possible approaches to problems or suggesting new interpretation of data. Proper review and adaptation of scientific literature will be required to develop complex scientific procedures and to remain current with continual advances in scientific knowledge. The candidate should have the ability to solve problems with experiments and equipment independently. Duties may include: Performing studies utilizing methods such as spatial genomics, RNAscope, confocal and light microscopy, immunohistochemistry; flow cytometry; preparation of retroviral vectors and transduction and expansion of T and NK cells for cell immunotherapy; and animal (mouse) handling. Duties will also include: summarizing, analyzing and interpreting data, statistical analysis of data, maintaining a scientific notebook, and presenting results at lab meetings and scientific meetings 15% Grant and manuscript preparation. 5% Assistance with oversight and management of the lab, lab staff, and students. This effort may be increased to train and oversee undergraduate student projects. Tasks may also include: general laboratory operation and maintenance, IACUC and IBC applications, and laboratory biosafety. Qualifications Essential Qualifications: Advanced degree (Ph.D., DVM, and/or MD) with a strong research background in microbiology, immunology, gene engineering, or biomedical sciences. Two or more years of postdoctoral research experience Preferred Qualifications Excellent oral and written communication skills Expertise with HIV, immunology, molecular biology, cell biology Experience with gene engineering, immunotherapy and in vivo models Experience with RNAScope, immunohistochemistry, and flow cytometry with methods such as: spatial genomics, RNAScope, immunohistochemistry, in situ hybridization, confocal imaging, gene engineering, retroviral transduction, real-time PCR, DNA sequence analysis and flow cytometry. Experience working with infectious agents, especially HIV, and animal models. Ability to independently write manuscripts. Track record of scientific research success including first author publications Benefits Working at the University At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work. The University also offers a comprehensive benefits package that includes: Competitive wages, paid holidays, and generous time off Continuous learning opportunities through professional training and degree-seeking programs supported by the Low-cost medical, dental, and pharmacy plans Healthcare and dependent care flexible spending accounts University HSA contributions Disability and employer-paid life insurance Employee wellbeing program Excellent retirement plans with employer contribution Public Service Loan Forgiveness (PSLF) Financial counseling services Employee Assistance Program with eight sessions of counseling at no cost Please visit the for more information regarding benefits. How To Apply Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume. Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section. To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-UOHR (8647). Diversity Employment Requirements Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment. About the U of M The University of Minnesota, Twin Cities (UMTC) The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations. The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds. The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu.