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Apply for Job Job ID364272 LocationTwin Cities Job FamilyAcademic Full/Part TimeFull-Time Regular/TemporaryRegular Job Code9546 Employee ClassAcad Prof and Admin Add to Favorite Jobs Email this Job About the Job Position Overview: In this position, you will be expected to conduct experiments characterizing limb ataxia in rodent models of spinocerebellar ataxia, and interrogate the underlying cerebellar physiology contributing to this ataxia. We work with a cued reaching task to quantify learned arm movements in mice. You will be expected to adapt this task to an induced end point error paradigm, and train healthy and mutant ATXN mice in this task, in order to examine how cerebellar-dependent adaptation is impacted in spinocerebellar ataxia. We also perform wide-field calcium imaging of the cerebellar cortex in awake animals, and you will be expected to perform simultaneous wide-field calcium imaging and behavioral monitoring in these same animals. Responsibilities Include: Research- 80% The candidate will develop and implement a rodent induced endpoint error reaching paradigm, and train healthy and mutant mice to perform this task. They will also learn to perform stereotactic surgeries in order to inject mutant mice with vectors to manipulate ATXN expression, induce calcium or voltage indicator expression, and implant animals with cerebellar windows for wide-field imaging. They will obtain high quality wide-field cerebellar imaging data in rodents performing the cued reaching task, and analyze the datasets using advanced analytical techniques. Operations - 10% The candidate will become familiar with the assigned literature, attend weekly lab meetings, participate in laboratory journal clubs, and report to the PI regularly on progress. They will also assist and eventually independently write study protocols, standard operating procedures (SOPs) manuscripts and grant applications. Presenting and Instruction - 10% The candidate will present research summary in national and international meetings in oral and poster format by preparing abstracts and slides for presentation. They will also instruct and mentor students, fellows and other inexperienced professional persons in proper laboratory methods and procedures. Qualifications Required Qualifications: A PhD in Neuroscience Previous laboratory experience with rodents Previous experience with rodent models of Spinocerebellar ataxia Experience with genetic manipulations in various rodent models of spinocerebellar ataxia Experience with tools to quantify and analyze rodent behavior behavior Demonstrated record of research accomplishments. Able to work independently and as part of a team. Preferred Qualifications: Basic knowledge of common histological preparations Experience with manuscript and grant writing About the Department Neuroscience is the scientific study of the nervous system. It is an interdisciplinary science that collaborates with other fields such as chemistry, computer science, engineering, linguistics, mathematics, medicine and allied disciplines, philosophy, physics, and psychology. The Department of Neuroscience is committed to providing excellence in research, education, and public service. The Department of Neuroscience is part of the University of Minnesota's Medical School. Benefits Working at the University At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work. The University also offers a comprehensive benefits package that includes: Competitive wages, paid holidays, and generous time off Continuous learning opportunities through professional training and degree-seeking programs supported by the Regents Tuition Benefit Program Low-cost medical, dental, and pharmacy plans Healthcare and dependent care flexible spending accounts University HSA contributions Dis bility and employer-paid life insurance Employee wellbeing program Excellent retirement plans with employer contribution Public Service Loan Forgiveness (PSLF) opportunity Financial counseling services Employee Assistance Program with eight sessions of counseling at no cost Employee Transit Pass with free or reduced rates in the Twin Cities metro area Please visit the Office of Human Resources website for more information regarding benefits. How To Apply Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume. Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section. To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-8647. Diversity Employment Requirements Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment. About the U of M The University of Minnesota, Twin Cities (UMTC) The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations. At the University of Minnesota, we are proud to be recognized by the Star Tribune as a Top Workplace for 2021, as well as by Forbes as Best Employers for Women and one of America's Best Employers (2015, 2018, 2019, 2023), Best Employer for Diversity (2019, 2020), Best Employer for New Grads (2018, 2019), and Best Employer by State (2019, 2022). The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds. The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu.