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St. Jude Children's Research Hospital Bioinformatics Research Scientist in Memphis, Tennessee

St. Jude is developing a comprehensive effort to study the immune system in cancer patients, with particular applications aimed at developing and refining immunotherapy approaches. For this effort, bioinformatics is critical, and we are actively searching for a highly motivated scientist who will serve as an informatic bridge between the Departments of Immunology and Bone Marrow Transplant & Cellular Therapy. In addition to spanning these two departments, you will be part of the Thomas Lab and will report to the Director of Immunoinformatics. Working alongside other bioinformaticians, clinicians, and staff scientists, you will have numerous opportunities to be involved in cutting-edge immunological research with direct translational applications, including analysis of near real-time data obtained from ongoing clinical trials. This work will in part entail the development, evaluation, and utilization of novel analytical tools related to bulk and single-cell expression and epigenetic analyses, including processes related to data processing, statistical analysis, network analysis, and data visualization; as such, this is a prime opportunity to develop expertise in the burgeoning field of single-cell bioinformatics broadly and in areas of cancer immunotherapy specifically.

Experience in R is required, and previous experience analyzing single-cell gene expression data is highly desirable but not required. Experience with general-purpose programming languages (C/C++, JavaScript, or PHP) preferred but not required. Background in molecular biology, cell biology, immunology, and/or cancer biology, wetlab environment, and familiarity with next-generation sequence analysis are highly preferred. Ability to effectively multitask and communicate clearly are both integral to success in this position.

  • Participates in the Department of Immunology’s independent research under the direction of the Director of Immunoinformatics, assisting with the analysis and interpretation of data.

  • Leads the development and establishment of standard analytical workflows for assigned projects.

  • Contributes to the preparation and submission of manuscripts for publication as needed, including drafting and editing methods, results, and discussion of the research.

  • Participates in collaborative research with interdepartmental investigators in basic and clinical research, particularly within the realms of cancer immunotherapy studies.

  • Formulates analytical plans that use the best approach to address challenging data analysis questions.

  • Maintains scientific knowledge base in immunology and bioinformatics topics by reading published literature, giving presentations, and attending relevant talks or conferences.

  • Gives public presentations to collaborators and team members to report scientific discoveries and educate researchers about relevant methods, software or scientific results.

  • Develops novel analytical procedures for unmet needs in the field of immunology as determined by the Director of Immunoinformatics. Contributes ideas to automate or improve existing analysis methods. Implements the improvement or works with others to do so.

  • Assists with establishing and documenting protocols or best practices for common research tasks.

  • Learns new bioinformatics techniques (e.g., programming, Next-generation sequencing, and statistics) to meet the needs of interdepartmental investigators.

  • Assists investigators in finding and using available bioinformatics software to address research needs.

  • Maintains regular and predictable attendance.

  • Performs other duties as assigned to meet the goals and objectives of the department and institution.

  • Bachelor's degree is required

  • Seven (7) years of relevant post-degree work experience is required

  • Five (5) years of relevant post-degree work experience is required with a Master's degree

  • Two (2) years of relevant post-degree work experience is required with a PhD

St. Jude is an Equal Opportunity EmployerNo Search Firms:St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.COVID-19 vaccine:St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.

Posted Job Title: Bioinformatics Research Scientist

WITS Req ID: 48378

Posted Department: Translational Immuno-Oncology

Street: 262 Danny Thomas Place