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Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok (https://www.tiktok.com/@abbvie) .

Job Description

The job that makes possibilities real in patients' lives. And yours.

The job that helps you get ahead in life. Moving mountains together.

Welcome to AbbVie! As part of an international company with 48,000 employees worldwide and around 3,000 employees in Germany, you will have the opportunity of addressing some of tomorrows unmet medical needs in close collaboration with your colleagues. Are you passionate about improving global health care? Do you want to contribute to improving patients' quality of life through your expertise? In a challenging work environment that offers opportunities of developing and increasing your own skills? Youve come to the right place!

Moving mountains together – as PBPK Modeler (all genders) (permanent / full-time)

The Quantitative, Translational and ADME Sciences (QTAS) team at AbbVie, Inc. is seeking a scientist in the Germany who can perform a role as Physiologically-Based Pharmacokinetics (PBPK) modeler to provide small molecule project support across multiple therapeutic areas. The successful candidate will be responsible for conducting static and mechanistic PBPK, human PK, and drug-drug interactions (DDI) projections using in vitro and in vivo ADME/PK data to support Discovery and Development project teams, enabling compound progression from discovery to early stages of clinical development. The position will require close collaboration with lab functions within QTAS, Discovery project teams and other R&D stakeholders in order to develop and execute QTAS strategies necessary to select and facilitate the advancement of optimized candidate molecules. In this exciting and dynamic role you will also be expected to evaluate new technologies and approaches to support the mechanistic and translational understanding of drug disposition and drug-drug interactions. The ideal candidate will have strong background and hands-on experiences in PBPK modeling using a commercial software (e.g. Simcyp).

Responsibilities

• Predict human PK and DDI profiles of small molecule drug candidates utilizing pre-clinical in vitro and in vivo ADME/PK data and static and mechanistic modeling tools

• Support project teams across multiple therapeutic areas and interpret results through close partnership with QTAS representatives

• Effectively communicate human PK/DDI prediction and PBPK modeling, QTAS strategy and knowledge to project teams, functional leaders, and other key stakeholders to ensure alignment and influence decisions

• Demonstrate thorough understanding of drug metabolism, pharmacokinetics and bioanalysis (DMPK-BA) necessary for the characterization of small molecule drug candidates to support regulatory submissions

• Stay current with latest developments in the field of human PK and DDI predictions including empirical (e.g. allomeric scaling) and more mechanistic models (e.g. PBPK)

Qualifications

• Doctorate (Ph.D.) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacology, Biomedical Engineering or related field with at least 2 years of experience in the pharmaceutical or biotechnology industries

• Experience with relevant modeling software, including Simcyp and Phoenix WinNonlin is required

• Hands-on project experience in PBPK modeling and simulation through direct industry experience as well as knowledge of regulatory expectations regarding PBPK modeling is preferred

• Experience in the field of DMPK with a general understanding of one or more disciplines within DMPK and knowledgeable in one or more of the following areas: in vitro ADME, pharmacokinetics, transporter, DDI, translational modeling, biotransformation, biomarker strategy

• Demonstrated publication record; lead/senior author contributions a plus

• Ability to influence, negotiate and communicate effectively with both internal and external stakeholders; ability to work well in a collaborative fast-paced team environment

• Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as team player and project driver

• High degree of flexibility in adapting to different projects and people; excellent networking and relationship-building (both internal and external) skills

• Passion for data analysis, solving technical problems and applying new technologies to further scientific goals

Key Leadership Competencies:

• Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance

• Learns fast, grasps the "essence" and can change course quickly where indicated

• Raises the bar and is never satisfied with the status quo

• Creates a learning environment, open to suggestions and experimentation for improvement

• Embraces the ideas of others, nurtures innovation and manages innovation to reality

Here's how we can move mountains together

• with a diverse work environment where you can have a real impact

• with an open corporate culture

• with an attractive salary

• with an intensive onboarding process with a mentor at your side

• with flexible work models for a healthy work-life balance

• with a corporate health management that offers comprehensive health and exercise programs

• with company social benefits

• with a wide range of career opportunities in an international organization

• with top-tier, attractive development opportunities

• with a strong international network

Multiple times, we have been globally recognized as a "Great Place to Work" and we are proud to provide our employees with the flexibility to maintain a healthy work-life balance. We take our impact on the environment and our communities seriously and therefore focus on giving something back on a regular basis. We are committed to equality, equity, diversity and inclusion (EED&I) – a commitment that is fundamental to us. This includes appreciating different perspectives, creating an inclusive culture and treating all employees with dignity and respect.

At AbbVie, your individual contributions count – help us move mountains together. Be a part of our success, grow with us and accomplish more than you could have imagined. Sounds like the perfect career opportunity for you? We look forward to receiving your application! All you need is a complete CV – we will discuss everything else with you in person.

Have questions? Email TalentAcquisition.de@abbvie.com – We look forward to hearing from you!

Additional Information

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html