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BSD SRF - Office of Shared Research Facilities

About the Department

The Human Immunologic Monitoring (HIM) facility serves as a specialized laboratory performing correlative assays and clinical specimen biobanking for cancer-based clinical trials. We participate in project development to assist in assay selection and optimization prior to study initiation. We offer a pick-up service for specimens from patients at the U of C Hospital or outpatient clinics, and process the samples as indicated for the assays being performed. For some studies, isolation and freezing of serum and peripheral blood mononuclear cells for analysis at a later date is performed, while for others immediate staining of whole blood for specific cell surface markers of interest is carried out. In addition, our laboratory prepares clinical grade products, such as peptide vaccines, for administration into patients.

Assays performed include a wide variety of immunology-based assays such as ELISA, ELISPOT, tetramer binding assays, detection of cell surface markers by flow cytometry, and biochemical assays such as Western Blots. We also perform molecular biology assays such as RNA extraction from tumor biopsies and either real time RT-PCR for specific transcripts or preparation of samples for bulk or single cell RNAseq. Tumor biopsies are analyzed by spatial transcriptomics and multi-spectral immune fluorescence. Stool samples are prepared for microbiome sequencing and metabolomic analysis. Our facility is equipped with 10X Genomics Chromium iX controller, 10X Genomics CytAssist, EVOS M7000 Imaging System, Vectra Polaris automated quantitative pathology imaging station, Nanostring nCounter analysis system, Isoplexis Isolight system, ELISPOT reader, PCR thermocyclers, CO2 incubators, biosafety cabinets, anaerobic chamber, centrifuges, and equipment for Western blot analysis. Although we perform assays on human samples, consideration will be given to expanding these services to mouse-model systems.

This at-will position is wholly or partially funded by contractual grant funding which is renewed under provisions set by the grantor of the contract. Employment will be contingent upon the continued receipt of these grant funds and satisfactory job performance.

Job Summary

The job manages scientific research projects or scientific research facilities. Uses considerable on-the-job experience to ensure compliance of research activities with institutional, state, and federal regulatory policies. Works independently to write articles, reports and manuscripts, and presents research findings at meetings and/or conferences.

The Director is responsible for planning, organizing and managing administrative functions and for overseeing technical operations of the HIM facility. Develop and implement new monitoring assays for clinical/translational studies. Establish new assay procedures and create SOPs. Manage clinical specimen logistics and storage. Prepare reports and drafts for grant proposals and scientific paper publications. Oversee technicians, maintain fee structures and chargeback accounts, and perform general laboratory management.

Responsibilities

• Responsibilities include development of new monitoring assays for clinical/translational studies.
• Establish new assay procedures and create SOPs.
• Manage clinical specimen logistics and storage.
• Prepare reports and drafts for grant proposals and scientific paper publications.
• Oversee technicians, maintain fee structures and chargeback accounts, and perform general laboratory management.
• Responsible for administrative function for the HIM including: generating operating and capital budgets, monitoring financial performance, hiring, raining and supervising staff.
• Manage supply and reagents inventory; selection and maintenance of equipment; facilities management, information services, quality assurance practices.
• Adherence with compliance, accreditation and other regulatory requirements as well as institutional policies and procedures.
• Participate in the research study designs and generation of grant proposals, as well as performance of experiments and doing some of the assays in the facility.
• Manage workflow and execution of research operations of the HIM based upon policies, procedures and practices developed in conjunction with Faculty Director.
• Interact regularly with various Hospitals-University of Chicago - Cancer Research Center personnel while performing the responsibilities of the job.
• Uses subject matter and best practices knowledge to perform lab and/or research-related duties and tasks. Works independently to assist with project design.
• Solves complex problems relating to the administration of projects, including planning new procedures, adapting existing procedures to the needs of the project, and making significant contributions to methodology.
• Performs other related work as needed.

Minimum Qualifications

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