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The University of Chicago Research Assistant - JR11210 in Chicago, Illinois

This job was posted by https://illinoisjoblink.illinois.gov : For more information, please see: https://illinoisjoblink.illinois.gov/ada/r/jobs/8204468 Department n

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BSD OBG - Lengyel Lab

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nAbout the Department n

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The overall goal of the laboratory is to enhance our understanding of human ovarian cancer biology. Our laboratory studies the role of the microenvironment in ovarian cancer development and progression; using knowledge gained to develop novel treatments for metastatic ovarian cancer. The approaches we take encompass primary cell and organ culture, mammalian cell culture, molecular biology, structural biochemistry, biochemistry, genomics, and transgenic mouse models. As a translational research laboratory, we have access to primary human tissue, including tissue microarrays of ovarian cancer. We collaborate with the pharmaceutical industry to test new compounds for ovarian cancer treatment in vitro and in vivo, and are part of phase I and phase II clinical studies examining new treatments for gynecologic cancers. The laboratory currently employs five postdoctoral scientists, 2 staff scientists, seven research support assistants and two research professors, and is situated in the Gordon Center for Integrative Science at the University of Chicago. The Center provides laboratory space for approximately 40 different research groups and encourages an integrative approach to science by bringing a Howard Hughes Medical Institute, biochemists, structural biologists, chemists, and cancer biologists together under one roof. We offer comprehensive and structured training in translational research with access to all aspects of basic and clinical cancer treatment. A strong background in molecular and cellular biology is important and expertise in protein biochemistry and/or transgenic mouse models preferred. We are seeking candidates who are self-motivated, career-oriented and able to take full advantage of the opportunities given. Our approach to science is highly collaborative.

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nJob Summary n

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The job performs routine assignments related to scientific research projects. Ensures compliance of research activities with institutional, state, and federal regulatory policies, procedures, directives and mandates. Analyzes possible solutions using standard procedures. Writes articles, reports and manuscripts. Assists in drafting presentations on research findings.

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nResponsibilities n

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+ Investigate the immune microenvironment of ovarian and endometrial carcinosarcoma, and will involve human tissue, in vivo mouse models, three-dimensional organotypic, and primary cell models to perform translational research. Work collaboratively with the principal investigators, fellows, students and other research specialists.


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+ Assists in organizing and managing the laboratory


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+ Participates in writing reports and manuscripts


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+ Works collaboratively with the team and collaborators


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+ Assists in management of animal colony and animal experiments


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+ Conducts periodic training for current and new members of the laboratory


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+ Contributes to, and sometimes leads, the writing of academic papers, reports and final summaries


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+ Collects, records, and analyzes data


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+ Assists with planning, development, and execution of related clinical research.


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+ Conducts literature reviews


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+ Ensures compliance with institutional, state, and federal regulatory policies, procedures, directives, and mandates


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+ Presenting research findings at staff meetings, seminars, and scientific conferences


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+ Analyzes and maintains data and/or specimens. Conducts literature reviews. Assists with preparation of reports, manuscripts and other documents


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+ Installs, sets up and performs experiments; interacting with students and other laboratory staff under the direction of the principal investigator


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+ Performs other related work as needed


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nMinimum Qualifications n

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nEducation: n

Minimum requirements include a college or university degree in related field.

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Work Experience: n

Minimum requirements include knowledge and skills developed through < 2 years of work experience in a related job discipline.

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Certifications: n

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nPreferred Qualifications n

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nEducation: n

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+ Bachelor's degree in field relevant to the research (e.g., biology, cell biology, cancer biology)


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nExperience: n

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+ At least two years of relevant research experience, including:


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+ Molecular Biology techniques (i.e. quantitative real-time PCR, RNA and DNA isolation, transfection, infection, transformation, cloning)


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+ Biochemical techniques (i.e. immunoblots, affinity chromatography)


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+ Tissue Culture techniques (i.e. ex vivo cultures, primary cell isolation, transfection, infection, co-culture, three-dimensional modeling)


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+ Cell assays (i.e. adhesion, migration, invasion, proliferation, apoptosis, cytotoxicity)


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+ Drug screening


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+ Microscopy (i.e. immunofluorescent analysis, wound healing assay, immunohistochemical analysis)


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+ Mouse in vivo models of cancer metastasis (i.e

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