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Sage Therapeutics Senior Medical Director, Medical Affairs in Cambridge, Massachusetts

General Scope and Summary

SAGE Therapeutics is searching for a creative, resourceful, integrative thinker for a highly visible role that is responsible for collaborating with other Medical Directors to lead medical and strategy and real-life data generation activities for the depression franchise. The position is responsible for providing subject matter expertise in development and execution of the strategic pre-approval and lifecycle tactical brand plans as they pertain to Medical Affairs activities, including collaboration with Key National Opinion Leaders to guide medical strategy, as well as the provision of strategic guidance and oversight over field teams, early access, Phase 3b/4 clinical trial programs, and investigator initiated research (IIR).

Roles and Responsibilities

  • Collaborate with group of depression franchise Medical Directors in support of medical strategic needs of brand programs.

  • Participate as a member of the Medical Affairs Leadership Team.

  • Collaborate with the Preclinical, Clinical Development, and Medical Affairs teams to translate clinical insights and data gaps into medical strategy.

  • Responsible for cultivating partnerships with cross-functional partners such as Clinical Development, Translational Science, Discovery, Patient Safety, Regulatory, Operations, Program Management, and Marketing to provide medical leadership in support of relevant therapeutic and disease area initiatives.

  • Assist in the leadership of lifecycle management, including but not limited to Phase 3b/4 and post hoc analysis of data.

  • Work closely with Medical Sciences and Clinical Operations to ensure optimal collaboration and inclusion of external clinicians/KOLs in clinical trial planning, enrollment, and interpretation.

  • Interact with various investigators, KOLs, research institutions, and internal Sage departments to oversee and facilitate Medical Affairs objectives and ensure the medical and scientific merit of company activities.

  • Support short and long-term goals of Medical Affairs with respect to prioritization of research interests and prioritization of desired collaborations with specific investigators and institutions.

  • Provide oversight and leadership in review and approval of external resources, communication, and publications to ensure medical accuracy, objectivity, and fair-balance.

  • Serve as a member of SMLR and PMRC, working with internal stakeholders at the initiation, creation, and review of educational and promotional materials. Provide medical expertise in review and approval of external resources, communication, and publications to ensure medical accuracy, objectivity, and fair-balance.

  • Facilitate cross-functional team (Medical Sciences, Medical Communication, Data Science, and Development teams) to perform post-hoc data analyses and identify opportunities to address clinical data gaps.

  • Collaborate with Medical Directors on the planning and execution of advisory boards with healthcare providers (physicians, nurses, nurse practitioners, pharmacists, etc.) to collect needed clinical insights to inform medical strategy.

  • Manage and regularly meet with a network of national thought leaders to support the successful execution of Medical Affairs tactics.

  • Represent Sage at various scientific and clinical congress meetings.

  • Interact with other departments, including Commercial, Clinical, Safety, Legal, and Regulatory.

Experience, Education and Specialized Knowledge and Skills

Must thrive working in a fast-paced, innovative environment while remaining flexible, proactive, resourceful, and efficient. Must have excellent interpersonal skills, the ability to develop important relationships with key stakeholders, good conflict management and negotiation skills, and the ability to analyze complex issues to develop relevant and realistic plans, programs, and recommendations. Must have a demonstrated ability to translate strategy into action, excellent analytical skills, and an ability to communicate complex issues in a simple way and to orchestrate plans to resolve issues and mitigate risks.

Basic Qualifications

  • MD, DO, or PhD/PharmD required.

  • 7+ years of prior industry experience as Medical Director and experience in psychiatry.

Preferred Qualifications

  • Experience navigating joint collaborations with biotech companies.

  • Is seen as a scientific leader and collaborative partner to internal and external stakeholders.

  • Prior experience developing medical strategic and tactical plans in support of drug launch is highly preferred.

  • Sets and maintains high standards for self and team in area of responsibility.

  • Must possess excellent communication skills, relationship building capabilities, and proven ability to influence decision-making without authority.

  • Is able to manage and lead others through complex issues where there is no clear cut "right" answer and when there are conflicting needs within the organization.

  • Is able to perceive non-obvious opportunities by connecting the dots between existing knowledge, new data, and HCP unmet needs in real time.

  • Must be highly perceptive, socially intelligent, and intuitive.

  • Leadership skills, including a passion for working within multiple teams and proven ability to achieve results in a matrix organization.

  • Consistently and systematically collaborates with internal stakeholders to plan approach to bring meaningful value to healthcare providers.

  • Highly motivated, decisive, and results-oriented individual with the flexibility and creativity to excel in a rapidly growing and changing environment.

  • Ability to flexibly tailor effective communication to multiple social styles.

  • Must embrace Sage’s Core Values: Put People First, Improve Lives, Cultivate Curiosity, Do Right, and Forge New Pathways.

Benefits and Compensation

The base salary hiring range for this position is $226,979 - $312,096.*

  • The actual salary offered within the range is dependent on a variety of factors including, but not limited to, relevant experience, qualifications, education, skills, and performance.

  • This position is eligible to participate in the Company’s annual bonus plan; the bonus varies based on performance and is subject to the standard terms and conditions of the incentive program.

  • To support your well-being, we offer a comprehensive benefits and wellness package, which includes medical, dental, and vision coverage upon hire. More information can be found in our Benefits Guide (https://careers.sagerx.com/media/ngth5cdv/sage-us-benefits-guide.pdf) .

*Base salary ranges are periodically reviewed and subject to change.


Protected personal characteristics include: age, race, ancestry, color, sex, national origin, sexual orientation, gender identity or expression, religious creed, mental or physical disability, pregnancy, genetic information, marital or civil union status, participation in the uniformed services of the United States, or any other characteristic protected under applicable federal, state or local law. To learn more, see Sage's Anti-Harassment and Equal Opportunity Policy