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Group Leader, Translational Medicine - Immuno Oncology (Senior Director)

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

This position is based in Cambridge, MA. Remote work from certain states may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines. Candidates interested in remote work are encouraged to apply.

Purpose and Scope:

The primary purpose of the Translational Medicine Group Leader is to lead the development and implementation of the Translational Medicine strategy within a defined disease or primary focus area. This position is responsible for developing the translational strategies for Astellas assets, taking accountability for day-to-day delivery aligned with approved plans/budgets. Incumbent will develop and execute, through self and others, the translational science/medicine programs with mechanistically-based biomarker and patient selection strategies for Astellas.

Essential Job Responsibilities:

• Leads a team of Translational Medicine scientists, within a defined disease or primary focus area, to advance Astellas therapeutic area pipeline from Candidate Nomination (CN) to Proof-of-Concept (POC) to commercial launch.

• Develops a portfolio level Translational Medicine strategy informed by disease insights and benchmarked against key competitors.

• Partners with Primary Focus (PF) Development to contribute to design of overall development strategy and trial design, incorporating biomarker endpoints.

• Represents Translational Medicine on PF-LT and provides scientific and strategic guidance to portfolio and asset teams, including business development strategic partnerships.

• Builds and maintains strong internal and external collaborations including partnership with Research to drive increased quality of CN candidates.

• Drives innovation and incorporates new approaches and cutting-edge technologies to increase PTRS and efficiency.

• Provides optimal project resourcing and supports delivery of portfolio by targeting key project issues aligned with overall portfolio prioritization.

• Mentors and supports team members to develop high levels of productivity and engagement whilst also responsible for performance management of the group.

• Reports to Head of Translational Medicine and expected to dedicate 50% of time as GTML

• Performs other duties as assigned or special projects as needed.

Qualifications Required:

• Advanced science degree (PhD, PharmD, or MD).

• Typically 12+ years of relevant experience in drug discovery and development in biotech/pharmaceutical company or equivalent translational research experience at an academic institution.

• First-hand experience in the identification and validation of pharmacodynamic and patient selection biomarkers, biomarker assay qualification and clinical implementation.

• Extensive early development experience and demonstrated success in generating Translational Science/Translational Medicine deliverables that contributed to POC.

• A strong track record in delivering high quality translational science and clinical biomarker data to inform decisions and development strategy.

• Broad technical experience in commonly used biomarker assay technologies and fit-for-purpose assay qualification/validation.

• An innovation mindset with track record of incorporating new technologies in translational and biomarker research.

• Proven record of leading teams, developing people and obtaining high quality and timely results through influencing in a matrix environment.

• Ability to work in cross-functional teams and to inspire and develop a team of translational medicine leads is essential to the success of this position.

Preferred:

• Experience in developing external collaborations.

• Experience in all phases of drug development.

Working Environment:

• This position is a hybrid role and can be based in US, Japan, UK or EU. Co-location within a globally recognized scientific center of excellence would be considered advantageous.

• At Astellas we recognize the importance of work/life balance, and we are proud to offer a hybrid working solution allowing time to connect with colleagues at the office with the flexibility to also work from home. We believe this will optimize the most productive work environment for all employees to succeed and deliver. Hybrid work from certain locations may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines.

Benefits:

• Medical, Dental and Vision Insurance

• Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks

• 401(k) match and annual company contribution

• Company paid life insurance

• Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

• Long Term Incentive Plan for eligible positions

• Referral bonus program

Compensation: $219,800 – 293,000 (NOTE: Final salary could be more or less, commensurate with experience)

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.

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Category Translational Medicine

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans