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Job Description

We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal to take our company’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

Discovery Biologics in Boston, MA is seeking a Senior Scientist to join our Cell Therapy group and expand our capabilities to engineer and characterize cell therapies. We aspire to develop new cell engineering technologies, uncovering new biology, and inventing the next wave of cell therapies to improve human health. The Cell Therapy group is part of the Discovery Biologics organization, which leverages machine learning, advanced automation, ultra-high throughput in vitro and in vivo technologies, and state-of-the-art characterization methods to develop biologics.

In this role, the successful candidate will contribute directly to the invention and evaluation of novel cell therapies. They will leverage skills in molecular biology and apply synthetic biology approaches to enable the design and engineering of chimeric antigen receptors (CAR), inducible/gated tumor targeting circuits and armored immune cells. As part of project teams, they will collaborate across groups to solve complex problems in immune cell biology and drug discovery. They will attend scientific conferences, contribute to publications, and help to set the group strategy. The successful candidate will join a diverse group of innovative scientists and engineers that are driving the next revolution in biologics discovery and engineering.

We recognize that the diversity in our team is our strength and are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of scientists to drive our core mission.

Responsibilities:

• Design CAR and DNA/RNA constructs for cell therapy, catalogue sequence information and generated materials

• Conduct molecular biology and in vitro cellular assays to support engineering for cellular potency in vitro and efficacy in vivo

• Collaborate with colleagues in the Cell Therapy group and across functional groups to establish engineering and screening platforms to rapidly prototype and engineer cells in an iterative design-make-test-learn approach

• Design study plans, record results in electronic lab notebook, analyze findings and present in internal group meetings

• Contribute to and lead the authoring of scientific publications and patents

• Support lab operations and manage efforts with CROs

• Stay current with scientific and technological development in immune cell therapy

Qualifications and Experience:

• PhD and/or postdoctoral experience in Molecular Biology, Bioengineering, Immunology, or a related field with 0+ years or MS with 5+ years or BS with 8+ years discovery experience in CAR engineering for cell therapy.

• Significant expertise in molecular biology with strong hands-on experience in recombinant DNA technologies

• Previous experience and knowledge in synthetic design and protein engineering in the context of engineering CAR cell therapy for improving tumor targeting specificity and/or enhancing immune cell potency and persistence

• Excellent communication and organizational skills

• Attention to detail and being comfort in working with an exploratory process

​

Required skills:

• Deep understanding of sequence and function relationship of synthetic immune receptor (e.g., CAR, TRuC, TCR)

• Hands on experience with DNA sequence design and optimization for lentiviral or non-viral vectors for T cell engineering and inducible gene expression cassettes

• Familiar with ex vivo T cell engineering using lentiviral vector and T cell culture, as well as cancer cell line culture

• Familiar with sequence design and data analysis software (e.g., Geneious, SnapGene, Prism, Flowjo)

Preferred skills:

• Experience with pooled or arrayed high throughput miniaturized immune cell engineering and screening

• Knowledge of producing lentiviral/retroviral vector for primary T cell engineering, non-viral T cell engineering with CRISPR-mediated gene editing or mRNA

• Experience with engineering allogeneic T cell therapy (e.g., abT, gdT, NKT) with scalable culture approach (e.g., G-Rex) and functional testing

• Experience with mouse T cell engineering

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

1st - Day

Valid Driving License:

No

Hazardous Material(s):

n/a

Job Posting End Date:

10/9/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date: 10/09/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R311849