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Novartis Pharmaceuticals Research Scientist II – Antibody Discovery (80-100%) * in Basel, Switzerland

318664BR Job ID: 318664BR Job Description: 6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Biologics Center (NBC) is accommodated within the Novartis Institutes for BioMedical Research (NIBR). NBC, in collaboration with the disease areas and technical expert groups, builds the future biologics therapy pipeline of Novartis through the discovery and creation of new antibody, protein, nucleic acid and virus-based molecules. We are looking for a Research Scientist II who is highly motivated, flexible and an adaptive team player for the Discovery Technologies (DT) Group within NBC in Basel, Switzerland. You will participate in the generation of high quality therapeutic antibodies to initiate and competitively advance the NIBR biologics pipeline by independently performing antibody screening followed by binding and functional characterization. Your responsibilities: Your responsibilities include, but not limited to: • Apply multiple cutting-edge selection techniques to synthetic and immune antibody libraries, like phage display, yeast display, mammalian display, FACS sorting, plate-based screening. • Analyze and screen selection outputs by Next Generation Sequencing (NGS). • Sub-clone hits into expression vectors and produce them at micro-scale in a high-throughput manner. • Characterize binders’ properties in various affinity and activity assays, like ELISA, iQue, FACS, Octet, epitope binning, reporter gene assays. • Engineer and improve binders by means of affinity maturation or humanization. • Generate hypotheses to test, troubleshoot issues, design and execute the next set of experiments with the input from senior team members/manager. • Document the results in a detailed manner in Laboratory journal and in internal Databases. • Present research updates and participate constructively in working project teams and at laboratory group meetings. Be part of a team of 2-3 Research Scientists reporting to a Lab Head. \n\n\n\n Position Title: Research Scientist II – Antibody Discovery (80-100%) * Minimum requirements: What you’ll bring to the role: • MS in Biological Sciences with at least 2 years of laboratory experience in antibody discovery technologies, including at least one technology like phage, yeast and/or mammalian display. • Experience in antibody engineering is a plus. • Knowledge in flow cytometry (analysis and sorting) is desirable. • Solid background in molecular biology, cell biology, biochemistry, affinity and activity assays. • Excellent oral and written communication in English and interpersonal skills. Self-motivation, enthusiasm, and scientific curiosity. You’ll receive: In addition to outstanding benefits and competitive salary, you will: • Be part of a team that is generating high quality therapeutic antibodies to help patients. • Gain experience with a variety of cutting-edge antibody selection and screening techniques. • Work with the latest technologies and instrumentation. • Be part of a world-class organization dedicated to providing solutions to un-met medical needs. • Join an organization that is committed to your development and advancement. Why consider Novartis? 769 million lives were touched by Novartis medicines in 2020, and while we are proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working. We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what is possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do at Novartis! Commitment to Diversity & Inclusion: Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration, and empowers our people to unleash their full potential. *Some restrictions on flexible working options may apply and will be discussed during interview if applicable. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Job Type: Full Time Country: Switzerland Work Location: Basel Functional Area: Research & Development Division: NIBR Business Unit: BIOTHERAPEUTIC AND ANALYTICAL TECHNOLOGIES - NIBR Employment Type: Regular Company/Legal Entity: Novartis Pharma AG Shift Work: No

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