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Dr. Jeff Mumm’s laboratory (Wilmer Eye Institute, Johns Hopkins University) is seeking a Laboratory Manager . The goal of the research is to understand how neural circuits are formed, how they function, and how they can be regenerated. We utilize zebrafish for our studies due to significant advantages afforded by this model system. The most important advantage being that zebrafish have a robust regenerative capacity that extends even to the nervous system. We also use cell-type specific labelling methods and confocal microscopy to make movies of how cells develop and/or behave directly in living animals. In addition, the lab is conducting a chemical drug screen to identify small molecule compounds that enhance the ability of zebrafish to regenerate lost tissues. This multi-prong approach facilitates investigations that allow us to visualize how neural circuits are established and identify genetic factors that regulate regenerate. In addition, the chemical drug screen will serve to reveal possible therapeutic targets in various human degenerative diseases.

Specific Duties & Responsibilities

• The position will require a thorough understanding and vigilant implementation of standard scientific methods.

• Under minimal or no supervision, the Laboratory Manager will perform experiments by developing new or following established procedures and protocols in conjunction with the PI. The ideal candidate will be expected to help design the experiments, analyze the resulting data, work independently and manage daily research projects.

• The Laboratory Manager will be expected to apply critical analytical skills during assigned projects in order to identify key findings and trouble-shoot problems; attention to detail is extremely important.

• In addition, the Laboratory Manager will provide training to other individuals who may be assigned to the laboratory on a regular or temporary basis. In the absence of the PI, the Laboratory Manager will serve as the lead researcher addressing any concerns/questions.

• Specifically, the Laboratory Manager will perform and analyze experiments related to retinal regeneration in zebrafish, including but not limited to conduct routine assays analyzing small chemical compounds and/or genetic mutations for their ability to effect regeneration; creating transgenic animal models; conducting high-resolution microscopy.

• Experiments will be conducted independently and as part of a team with a diverse range of researchers (undergraduate students to postdoctoral fellows).

• Work with the PI to develop new or refine current experimental methodologies.

• Perform operational activities such as: monitoring inventory levels; procuring supplies and materials; assist with hiring staff; maintain and monitor various shared index databases interfacing with Hopkins Facilities/Vendors regarding broken equipment, invoices, supplies etc.

• Helps maintain and monitor a large Zebrafish facility.

• Will help ensure that all (institutional, state and federal) regulatory mandates are met.

• Will assist with ensuring that the lab is fiscally responsible.

• Helps manage junior research personnel and assist other research personnel in the lab as needed.

• Assist the PI with manuscript and/or grant preparation.

• May assist PI with some administrative duties (e.g. helping plan hosted meetings).

Minimum Qualifications

• Bachelor's Degree in Biology, Chemistry or related field.

• Five years related experience, including proven technical knowledge and laboratory experience.

• Master's degree, with related graduate research, may substitute for experience to the extent permitted by the JHU equivalency formula.

Preferred Qualifications

• Previous research related work experience with the following techniques/experiences: High resolution imaging (fluorescence and confocal microscopy), Histological and immunological tissue processing, and standard Molecular Biology techniques.

• Demonstrated mentoring/supervising experience is preferred.

• The Laboratory Manager must be able to work both independently and in a collaborative manner with a diverse group of researchers.

Classified Title: Laboratory Manager

Role/Level/Range: ACRP/04/MD

Starting Salary Range: $55,200 - $96,600 Annually (Commensurate with experience)

Employee group: Full Time

Schedule: Mon-Fri 8:00 – 5:00, 40 hrs with flexibility

Exempt Status: Exempt

Location: Hybrid/School of Medicine Campus

Department name: ​​​​​​​SOM Oph Ocular Genetics Research Center

Personnel area: School of Medicine

Equal Opportunity Employer:

Johns Hopkins University is an equal opportunity employer and does not discriminate on the basis of race, color, gender, religion, age, sexual orientation, national or ethnic origin, disability, marital status, veteran status, or any other occupationally irrelevant criteria. The university promotes affirmative action for minorities, women, disabled persons, and veterans.