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University of Michigan RESEARCH FELLOW in Ann Arbor, Michigan

RESEARCH FELLOW

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Summary

We are seeking highly motivated postdoctoral fellow candidates to join the laboratory of Brett McCray, MD, PhD, at the University of Michigan to lead studies elucidating mechanisms of hereditary neuromuscular disease. Our primary focus is on diseases caused by mutations in the ion channel TRPV4, which result in Charcot-Marie-Tooth disease type 2C and related forms of spinal muscular atrophy. In collaboration with Dr. McCray and other members of the laboratory, the fellow will contribute to the design, management, coordination, and implementation of in vitro and in vivo studies focused on defining mechanisms of disease pathogenesis. Specific potential pathogenic mechanisms to explore include the role of TRPV4 in regulating actin cytoskeletal dynamics and the integrity of blood-brain barriers. Candidates should have a doctoral degree and strong research background with expertise in molecular and cellular biology. This is an interdisciplinary project with opportunities to learn new skills in biochemistry, molecular and cellular biology, transcriptomics and proteomics, induced pluripotent stem cell culture/differentiation, and mouse models of disease. Opportunities to become involved in clinical research projects are also available.

Responsibilities*

  • Design, perform, analyze, and interpret experiments independently. Experimental approaches will include culture of immortalized and stem cell-derived cells; analysis of protein-protein interactions; generation of novel mammalian expression vectors; live imaging of calcium dynamics, cytoskeletal changes, and molecular biosensors; immunohistochemistry; mouse behavior and histology; and additional biochemistry and cellular biology approaches.

  • Organize and present data at scientific seminars and conferences

  • Write manuscripts for publication

  • Support mentorship of undergraduate students and technical personnel

  • Other duties as assigned

Required Qualifications*

  • Possess a Ph.D. in Neuroscience, Biochemistry, Cell Biology, or medical-related field with significant experience in molecular and cellular biology

  • Have strong oral and written communication skills

  • Have a positive, collaborative, and flexible attitude suitable for working in an academic laboratory environment

Desired Qualifications*

  • Experience with mouse husbandry, behavioral testing, and histology

  • Experience with fluorescence microscopy

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.

Job Detail

Job Opening ID

248707

Working Title

RESEARCH FELLOW

Job Title

RESEARCH FELLOW

Work Location

Ann Arbor Campus

Ann Arbor, MI

Full/Part Time

Full-Time

Regular/Temporary

Regular

FLSA Status

Exempt

Organizational Group

Medical School

Department

MM Neurology Department

Posting Begin/End Date

5/06/2024 - 6/06/2024

Career Interest

Research Fellows

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